In order to understand this relationship further, studies incorporating depressed non-TBI control subjects are needed, as well as imaging studies of mood and cognition in TBI patients. Major depression following TBI can readily respond to treatment, and there is indication that aspects of cognition may also improve with successful antidepressant treatment in this population.
It has the potential to substantially improve quality of life by addressing two significant sources of morbidity following TBI—namely, mood and cognitive dysfunction. This may ultimately translate into a reduced economic burden of TBI by allowing patients to return to work and resume a productive life. Feinstein is supported by funding from the Canadian Institute for Health Research. Rapoport and Feinstein are supported by an operating grant from the Ontario Neurotrauma Foundation.
The results and conclusions are those of the authors. The authors would like to thank Alison Jardine, Vicky Pelchat, and Andrea Phillips for their assistance with this research.
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Rapoport Search for more papers by this author. Scott McCullagh Search for more papers by this author.
Prathiba Shammi Search for more papers by this author. Anthony Feinstein Search for more papers by this author. Published Online: 1 Feb Add to favorites Download Citations Track Citations. Abstract Traumatic brain injury TBI and major depression are neuropsychiatric conditions that have been associated with cognitive dysfunction. Enlarge table. TABLE 2. Received April 11, ; revised June 10, ; accepted July 17, Address correspondence to Dr. Rapoport sw. Maryse C. Cnossen , M.
Scholten , Ph. Lingsma , Ph. Ewout W. Steyerberg , Ph. While pharmacological agents and sleep disturbances may differentially impact specific cognitive domains, they also tend to have significant generalized effects. Similarly, although a particular gene putatively influences a cognitive ability, relatively little evidence for specificity genetic effects among cognitive domains actually exists. Thus, while the study of cognition is often fractionated into discrete loci, in this Gordon conference we focus on cognition from a holistic, interconnected perspective.
By adopting a transdiagnostic and integrated approach, including basic animal, translational and clinical studies, we aim to shed light on how cognition develops and declines over the lifespan, how it is influenced by genetics genetic, the sleep-wake process, and in neuropsychiatric disorders.
We purposely choose leading experts from different areas of neuroscience, human neuropsychology, epidemiology, brain imaging and genetics to speak at a single meeting in an attempt to produce a more complete understating of cognition and how it is disrupted by disease. By integrating neurodevelopmental and neurodegenerative perspectives and basic, translational and clinical approaches, we believe a new understanding of the complexity and diversity of cognitive ability will emerge.
This understanding could lead to novel insights for future intervention strategies, from early detection to prevention of cognitive dysfunctions. The collegial atmosphere of this meeting, with programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented.
FAQs Instant answers to common questions. May 12 - 17, Vice Chairs Sandra S. Chan and Nicola Lautenschlager. Contact Chairs. Conference Description. Conference Program. Sunday pm - pm Arrival and Check-in. Genetic Influences on Cognitive Development This session will highlight the impact of genetic variation on cognitive and brain development as evidenced from work in non-human primates and human genetic epidemiology. Neurodegeneration: Genetic, Pathophysiology and Biomarkers of Alzheimer's Disease This session will highlight the search for the pathophysiology mechanism, biomarkers, neuroimaging and genetics of Alzheimer's disease.