Claus-Michael Lehr. Her main objective is to design fonctionnalized nanocarriers, for the smart delivery of anticancer compounds. Full time Professor of formulation and Head of Formulation and Sensory department at Ecole de Biologie Industrielle, Cergy, France management of panelists experts in sensory evaluation. Core research interest Improving the well-being of people is the main preoccupation of my research and that's why I started a research activity in the sensory science over 20 years ago.
[Full text] Recent advances in "smart" delivery systems for extended drug release | IJN
First focused on development of topical galenics, I have developed referential and methods adapted to the evaluation of these products. Today, my research field is wider and it integrates the studies of sensation, acceptability and emotion in a quality by design approach of variables formulations. This ensures design of product that meets the expectations of the consumers in terms of performance safety and acceptability. My research focusses on advices for oral administration with controlled drug release, based on polymer blends. I conducted research projects including Hot Melt Extruded matrices for improved release kinetics of practically water-insoluble drugs and polymeric film coatings for sustained drug release from pellets.
My research collaborations are reaching from international industrial partners to the European Union. My research interests are Oral solid dosage forms for sustained drug release, Hot-Melt extrusion with polymers and Polymeric Film Coating. J Mater Chem B ;— Dual turn-on fluorescence signal-based controlled release system for real-time monitoring of drug release dynamics in living cells and tumor tissues. Theranostics ;— Non-invasive, real-time reporting drug release in vitro and in vivo. In vivo and in situ tracking cancer chemotherapy by highly photostable NIR fluorescent theranostic prodrug.
Dual-channel NIR activatable theranostic prodrug for in vivo spatiotemporal tracking thiol-triggered chemotherapy. Chem Sci ;— A two-photon-activated prodrug for therapy and drug release monitoring. A dual-FRET-based versatile prodrug for real-time drug release monitoring and in situ therapeutic efficacy evaluation. Adv Funct Mater ;— Peryleneylmethanol: fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release. Perylene-derived single-component organic nanoparticles with tunable emission: efficient anticancer drug carriers with real-time monitoring of drug Release.
Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. Cancer Lett ;—9. Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release. Nanoscale ;— Fluorescent polymeric micelles containing fluorine derivatives for monitoring drug encapsulation and release. Colloid Polym Sci ;— Polymer nanoassemblies with solvato- and halo- fluorochromism for drug release monitoring and metastasis imaging. Ther Deliv ;— Long-term real-time in vivo drug release monitoring with AIE thermogelling polymer.
Small ; Glyco-nanovesicles with activatable near-infrared probes for real-time monitoring of drug release and targeted delivery. Chem Mater ;—6.
Journal of Drug Delivery Science and Technology
A sequence-activated and logic dual-channel fluorescent probe for tracking programmable drug release. J Appl Polym Sci ;—7. Adv Healthc Mater ;—8. Bioinspired fluorescent dipeptide nanoparticles for targeted cancer cell imaging and real-time monitoring of drug release.
enter Nat Nanotechnol ;— Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. Multifunctional magnetically removable nanogated lids of Fe 3 O 4 capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging.
J Mater Chem ;— Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. Graphene quantum dot-capped mesoporous silica nanoparticles through an acid-cleavable acetal bond for intracellular drug delivery and imaging. J Phys Chem C ;—6. Controlled delivery using oligonucleotide-capped mesoporous silica nanoparticles.
Angew Chem Int Ed ;— Glucose and pH responsive controlled release of cargo from protein gated carbohydrate-functionalized mesoporous silica nanocontainers. Angew Chem Int Ed ;—6.
In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers. Nat Commun ; Mesoporous silica particles as a lipophilic drug vehicle investigated by fluorescence lifetime imaging.
Monitoring pH-triggered drug release from radioluminescent nanocapsules with X-ray excited optical luminescence. Facile fabrication and application of near-IR light-responsive drug release system based on gold nanorods and phase change material.
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Smart yolk-shell type luminescent nanocomposites based on rare-earth complex for NIR-NIR monitor of drug release in chemotherapy. J Photochem Photobiol A ;— Chem Sci ; Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations. Direct organelle thermometry with fluorescence lifetime imaging microscopy in single myotubes. Quantum-sized carbon dots for bright and colorful photoluminescence.
J Am Chem Soc ;—7. Carbon dot-based inorganic-organic nanosystem for two-photon imaging and biosensing of pH variation in living cells and tissues. Adv Mater ;—8. Bioimaging of hyaluronic acid derivatives using nanosized carbon dots. Biomacromolecules ;— Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging.
Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging. Adv Mater ;— Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs. J Mater Chem B ;—8. Anal Chem ;— Silicon nanomaterials platform for bioimaging, biosensing, and cancer therapy. Acc Chem Res ;— Size and surface chemistry-dependent intracellular localization of luminescent silicon quantum dot aggregates.
J Mater Chem ;—8. Paramagnetic, silicon quantum dots for magnetic resonance and two-photon imaging of macrophages. Microwave-assisted synthesis of biofunctional and fluorescent silicon nanoparticles using proteins as hydrophilic ligands. Angew Chem Int Ed ;—9. Alkyl passivation and amphiphilic polymer coating of silicon nanocrystals for diagnostic imaging. Small ;— PET imaging and biodistribution of silicon quantum dots in mice. Co-encapsulation of biodegradable nanoparticles with silicon quantum dots and quercetin for monitored delivery.
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Adv Healthc Mater ;— Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect. J Mol Sci ;— Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Colloidal graphene quantum dots with well-defined structures.
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Focusing on luminescent graphene quantum dots: current status and future perspectives. Mater Chem Phys ;— Catalytic polymerization of N-methylthionine at electrochemically reduced graphene oxide electrodes. Electrochim Acta ;— Bansal A, Zhang, Y. Photocontrolled nanoparticle delivery systems for biomedical applications. Yang YM. Upconversion nanophosphors for use in bioimaging, therapy, drug delivery and bioassays. Microchim Acta ;— Upconversion nanoparticles in bioassays, optical imaging and therapy.